Topic: striatal astrocytes

After excitotoxic lesions, subsets of striatal astrocytes undergo spontaneous neurogenic activation, leading to the local generation of a large number of neuroblasts for at least six months post-lesion. However, the functional integration of the lesion-induced neurons remains unclear. Fate mapping and 3D reconstruction analyses reveal that striatal neuroblasts undergo a maturation process in which they initially organize in clusters, subsequently disperse as individual cells, and gradually attain complex morphologies, often exhibiting dendritic spines. These neurons fail to express typical mar

In the adult mammalian brain neural stem cells (NSCs) are considered rare cells restricted to two specialised niches, the subventricular zone (SVZ) and the subgranular zone. Recent findings demonstrated that in response to injury new neurons can be generated also by parenchymal astrocytes, however the prevalence, distribution, and behaviour of these ectopic NSCs remained elusive. Consequently, the extent to which the neurogenic potential of the mature brain parenchyma differs from that of conventional neurogenic niches remains to be determined. To tackle this issue, here, we reconstructed the