Topic: structural dynamics

Develop Bayesian calibration methods that explicitly represent model error in structural dynamics. The PLATON team will compare informative calibration quantities, implement and benchmark algorithms, and accelerate inference with surrogate models. The work aims to improve finite-element predictions under uncertain material, boundary and loading conditions. Applicants need a relevant doctorate and scientific-computing expertise, with experience in structural dynamics, model calibration or uncertainty quantification. Appointment: 12 months; advertised start 2027-01-01. 2788€ gross/month.

Evidence regarding protein structure and function manifest the imperative role that dynamics play in proteins, underlining reconsideration of the unanimated sequence-to-structure-to-function paradigm. Structural dynamics portray a heterogeneous energy landscape described by conformational ensembles where each structural representation can be responsible for unique functions or enable macromolecular assemblies. Using the human p27/Cdk2/Cyclin A ternary complex as an example, we highlight the vital role of intra- and intermolecular dynamics for target recognition, binding, and inhibition as a cr