Topic: subcortical areas

Sharp wave ripples (SWR) represent synchronized activity of neuronal population in the mammalian hippocampus. They are thought to be associated with memory reactivation, transfer, and consolidation during sleep and awake immobility. In adults, it was shown that some subtypes of SWR are triggering precise activation across cortical areas accompanied by strong inhibition in subcortical areas (Logothetis et. al. 2012, Pedrosa et. al 2022) while other subtypes preferentially activates neuromodulatory structures such as the dorsal raphe nucleus and the locus coeruleus (Ramirez-Villega et. al 2015).

Neural oscillations provide unique insights into brain function in health and disease. Recently, the non-sinusoidal waveform shape of oscillations has gained interest as a promising biomarker of underlying network physiology. However, the relationship between spiking activity and the oscillatory shape of population signals such as the local field potential (LFP) is unknown. To address this, we simultaneously recorded LFP and multi-unit spiking activity in 8 different cortical and subcortical brain areas of macaque monkeys. We applied Fourier-based waveform analysis to LFP oscillations and syst