Topic: Swiss mice

The noradrenergic (NA) system plays a critical role in memory consolidation, including declarative memory. Recognition memory, an important aspect of declarative memory, involves the ability to acquire and recall information to identify familiar stimulus. Novel Object Recognition (NOR) is a widely used task to assess this type of memory in rodents. This test is based on the innate preference for novelty and the ability to discriminate novel and familiar objects. Post-training yohimbine administration, an a2-adrenoceptor antagonist, enhances object location memory in mice, suggesting that incre

To justify animal experiments, all methods require State-of-the-Art techniques. Statistics belong to often ‘unloved’ methods but reduce subjects by biometrical predictions, statistical analyses, and, surprisingly, by correct identification, i.e. the experimental unit (EU). Per definition, the EU is the number of subjects that can be treated individually different within the experiment. Consequently, correct implementations of EUs increase animal numbers when ‘treatment’ applies grouped housed animals, because the cage, independent of number of animals, is the EU. Thus, either ignore sociabilit