Topic: αSyn

Alpha-synuclein (αSyn)-related pathology crucially contributes to the pathogenesis of Parkinson’s disease (PD), leading to progressive neuronal populations loss in specific brain regions. This results in the presence of both motor and non-motor symptoms in PD patients. Anxiety occurs at an early stage of the disease and is one of the most frequent neuropsychiatric symptoms in patients with PD, indicating pathology in the cortico-limbic system. This study aimed to decipher that the spread of αSyn pathology to a given brain region is sufficient to induce non-motor symptoms observed in PD patient

A growing body of evidence suggests a potential link between neuroinflammation, directly or indirectly triggered by viral infections, and the initiation or progression of neurodegenerative diseases such as Parkinson's disease (PD). Viral infections can potentially induce pathological alterations in amyloidogenic proteins such as a-synuclein (αSyn) implicated in pathogenesis of this disease. However, the exact molecular mechanisms of virus-induced neuroinflammation remain unclear.To get insights into mechanisms of viral RNA-induced neurotoxicity, we treated rat neuronal-glial co-cultures (CGC)