Topic: synapsins

Hippocampal mossy fiber boutons are giant, very plastic synapses that provide a strong and sparse input onto CA3 that is thought to be important for learning and memory. These synapses have a low basal release probability and display various forms of plasticity: frequency facilitation, post-tetanic potentiation (PTP), and a cAMP-dependent presynaptic form of long-term potentiation (LTP).Synapsins are the most abundant neuronal phosphoproteins. Due to their phosphorylation-dependent association with synaptic vesicles they play an important role in synaptic transmission and plasticity.Differentl

Synapsins are a family of synaptic vesicle phosphoproteins (SVs) playing a key role in synaptic transmission and neuronal development. Mutations of Syn genes lead to dysregulation in brain network functions implicated in the pathophysiology of neurological and psychiatric disorders. We aimed at investigating the impact of deletion of all three Syn isoforms on social and cognitive behavior in Syn triple knockout (TKO) mice and on the neuronal activity of the glutamatergic transmission in the infralimbic medial prefrontal cortex (IL-mPFC) and in hippocampal CA3 using in vivo electrophysiology. A

Neurotransmitter release relies on the regulated fusion of synaptic vesicles (SVs) that are tightly packed within the presynaptic bouton of neurons. The ability of SVs to dynamically recycle while remaining clustered at the presynapse is unknown but suggests anchoring mechanisms that regulate SV function. One potential anchor is a family of phosphoproteins that interact with presynaptic SVs, called synapsins. Synapsins tightly bind SVs and form biomolecular condensates via liquid-liquid phase separation which can potentially help trap SVs at the presynapse. An alternative model for synapsin’s