Topic: synaptic boutons

Neural responses in the visual system are usually not purely visual but depend on behavioural and internal states such as arousal. This dependence is seen both in primary visual cortex (V1) and in subcortical brain structures receiving direct retinal input. In this talk, I will show that modulation by behavioural state arises as early as in the output of the retina.To measure retinal activity in the awake, intact brain, we imaged the synaptic boutons of retinal axons in the superficial superior colliculus (sSC) of mice. The activity of about half of the boutons depended not only on vision but

Neuronal morphology plays a fundamental role in determining the neuronal network's function. However, understanding the effect of single neuron morphology on whole-brain function is still an open challenge. Limited by resolution and time cost, current studies on the functional properties of whole-brain connectivity are mainly described with simulations from the mesoscale perspective, like those generated in The Virtual Mouse Brain (TVMB) platform. Whole mouse brain activity is simulated using connectivity weights between brain regions obtained from tracer injections in populations of neurons a