Topic: synaptic genes

Emotions play an adaptive role in shaping neural representations of strong aversive memories. Complex mood disorders like post-traumatic stress disorder (PTSD), depression and anxiety share common symptoms of memory impairment, though their link to mechanisms of memory consolidation is not well understood. The strength of ensemble formation in micro- and macro-circuits between the central nucleus of the amygdala (cea) and the hypothalamic paraventricular nucleus (pvn) facilitates associations between different internal states, innate behaviour and aversive experiences. Understanding how ensemb

Schizophrenia is a neuropsychiatric syndrome that affects around 1% of the world population. It is characterized by psychotic or positive symptoms, negative symptoms and cognitive deficits. Currently, antipsychotic treatments can help to manage psychotic symptoms in acute episodes of schizophrenia. However, there is an unmet medical need for the treatment of those cognitive symptoms that appear since the premorbid phase and affect almost 98% of patients. Despite the identification of some molecular pathways that are impaired in schizophrenia, little is known about the possible contribution tha