Topic: synaptic integration

Synaptic integration is crucial for inter-neuronal communication, and excitatory-inhibitory integration is utterly important in lateral superior olive (LSO) neurons, enabling sound localization. For this purpose, LSO neurons integrate excitatory inputs from the ipsilateral cochlear nucleus (CN) with inhibitory inputs from the medial nucleus of the trapezoid body (MNTB). The strength and number of excitatory and inhibitory inputs show notable differences. The convergence of multiple excitatory input fibers (~10‑40) is a source for synaptic noise in the spike driving inputs. We focused on how sy

Newly developed voltage indicators require fast scanning methods for effective signal recordings. The flexibility of AO imaging allows us to measure in a three-dimensional volume not only at the somatic level, but also the dendrites. Their high scanning frequency makes AO microscopes suitable for dendritic signal processing and plasticity research. Soma dependent and independent dendritic activities are highly investigated areas, but the spatio-temporal limitations of electrophysiology and conventional one- or two-photon devices have serious constraints when it comes to GEVI imaging. Here we s