Topic: synaptic remodeling

Understanding the impact of forgetting is crucial in neuronal systems, particularly in how it affects the remodeling of neuronal circuitry. In this study we explore the role of forgetting in the context of reversal learning in mice, complemented by a simulated analysis of synaptic remodeling in a recurrent neural network.In our experiment, mice were trained to discriminate between two stimuli in a go/no-go task, followed by a retention test after intervals of either 2 or 16 days. This phase was succeeded by reversal learning, where the stimulus contingencies were switched. We observed that mic

Microglia continuously remodel synapses, which are embedded in the extracellular matrix (ECM). However, the mechanisms which govern this process remain elusive. To investigate the influence of the neural ECM in synaptic remodeling by microglia, we disrupted ECM integrity by injection of chondroitinase ABC (ChABC) into the retrosplenial cortex of healthy adult mice. Using in vivo two-photon microscopy we found that ChABC treatment increased microglial branching and ECM phagocytic capacity and decreased spine elimination rate under basal conditions. Moreover, ECM attenuation largely prevented sy