Topic: synaptic responses

The activity of neurons throughout the brain is determined by the precise relationship between excitatory and inhibitory inputs and disruption of this relationship underlies many psychiatric diseases. Whether these inputs covary over time or between repeated stimuli remains unclear due to the lack of experimental methods for measuring both inputs simultaneously. We developed a new analytical framework for simultaneous measurement of both the excitatory and inhibitory neuronal inputs during a single trial of a current clamp recording. This can be achieved by injecting a current composed of two

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with genetic and environmental origins. Alterations in sensory disturbance have been clinically linked to socio-emotional problems in individuals with ASD but remain understudied in the research field. Recent evidence has shown that the prefrontal cortex (PFC), a brain region plays an essential role in social cognition, is involved in pain management. Hence, this study aims to qualify nociceptive response of ASD and the implication of PFC. Valproate (VPA)-exposed offspring and Tsc2 heterozygous knockout (Tsc2+/-) mic

Alzheimer's disease (AD) develops undiagnosed for years. Diagnosis of AD remains relatively invasive and restricted to specialized centers calling for development of the new diagnostic markers. Retina may be an attractive source of such markers because it is an accessible part of the CNS (in vivo imaging and electrophysiology). Recent studies indicate pathological alterations in retina of AD patients such as retinal ganglion cell degeneration. Recently, we showed a dysfunction in the glutaminergic photoreceptor synapsis associated with a strong expression of phosphorylated tau proteins (p-tau)