Topic: synaptic targeting

Midbrain dopamine (DA) neurons possess complex branching structures and demand significant metabolic resources . This intricate architecture makes these neuron susceptible, emphasizing the role of intracellular trafficking in the early development of Parkinson's disease (PD). Recent genetic screenings in Asian and European populations have unveiled SV2C (synaptic vesicle glycoprotein C) as a newly discovered gene associated with PD. Specifically, the D543N mutation has been linked to PD. It is hypothesized that this mutation introduces a new glycosylation site in the SV2C protein, underscoring

To facilitate rapid changes in protein composition in axons and dendrites, neurons can translate mRNAs into proteins at distal sites. This machinery requires long-range transport of specific mRNAs, which are packaged into granules by RNA-binding proteins and carried by kinesin motor proteins along microtubule. Local mRNA translation is crucial for dendritic spine development and plasticity. Nonetheless, whether different mRNAs are distributed in a specific manner near synapses and how is their localization regulated after synaptic stimulation are not well-characterized. Consistent with previou