Topic: synaptophysin

Despite an increasing number of studies describing changes in dopamine brain regions and autism symptoms, the specific alterations in midbrain dopamine neurons projecting to the striatum remain unclear. Therefore, the aim of the present study was to examine the structural and morphological properties of primary dopaminergic neuronal cell cultures isolated from Shank3-deficient transgenic mouse, known for exhibiting autism-like symptomatology. Additionally, we evaluated the expression of selected synaptic proteins in the brain areas relevant for social behavior in wild type (WT) and Shank3-defi

Apolipoprotein E (ApoE) is the major glycoprotein in the brain and plays a critical role in the transport of cholesterol and other lipids. Besides, ApoE has a crucial function in the maintenance of synaptodendritic connections, and repair of neurons. ApoE knockout (ApoE-KO) mice model whose apoE gene has been knocked out has great importance for understanding the effect of ApoE and loss of function of ApoE. Scientists have reported cognitive impairment in ApoE-KO mice, with cholinergic deficits, decreased synaptic excitability. In the present study, we investigated the difference between the b