Topic: synaptopodin

Metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) is an important form of synaptic plasticity that occurs in many regions of the brain and is the underlying mechanism for several learning paradigms. In the hippocampus, mGluR-LTD is manifested by the weakening of synaptic transmission and elimination of dendritic spines. Interestingly, not all spines respond or undergo plasticity equally in response to mGluR-LTD. A subset of mature and more stable dendritic spines containing synaptopodin (SP), an actin-associated protein involved in local protein synthesis and calcium d

High-frequency oscillations (HFOs) have been observed to be particularly prominent in brain regions responsible for seizure initiation and propagation. Connexins play a crucial role in fast intercellular communication within the brain, as they are integral components of gap junctions, which facilitate direct cytoplasmic connections between neighboring cells. Recent studies identified clusters of connexins within the rodent CNS, specifically along the axon initial segment (AIS), a critical neuronal microdomain responsible for the initiation of action potentials. However, details about the subce