Topic: tactile perception

Chronic traumatic encephalopathy is a tauopathy resulting from repeated moderate-to-severe traumatic injuries onto the brain, leading to Tau protein abnormal posttranslational modifications, mislocalization, and deposits. Although the spinal cord shares a lot of structural and cellular similarities, most studies of CNS traumatic injuries were conducted onto the brain. In the present project, we emitted the hypothesis that repeated mild contusions onto the spinal cord could similarly exacerbate the tauopathy in a transgenic mouse expressing an aggregation-prone human mutated tau protein (hTauP3

Spinal cord injuries (SCI) often result in somatosensory system alterations and the development of chronic and neuropathic pain. Despite the availability of various treatments, pain remains refractory in many patients. In our study, we explore the potential benefits of powered exoskeleton training for individuals with SCI, focusing on its impact on tactile perception and neuropathic pain.Nineteen participants with traumatic SCI were recruited for our investigation. The lesion was below the T4 level for all participants. We evaluated changes using a computerized pressure algometer, the Numerica