Topic: tactile reversal learning

Adapting one’s decisions to changing contexts is a critical component of flexible behaviour. We recently identified that the orbitofrontal cortex plays an important role in signalling contextual switches in human tactile reversal learning. However, the neurobiological mechanisms that underlie such signals during behavioural flexibility remain unclear. To investigate this, we designed a probabilistic tactile ‘Go/No-go’ reversal learning task and simultaneously recorded brain-wide EEG responses from healthy participants. Participants first learned to associate specific braille stimuli with ‘Go’

Animals continuously evaluate past and current sensory and contextual information to make appropriate decisions during behaviour. How animals employ specific behavioural strategies while learning a task and how the orbitofrontal cortex (OFC) contributes to such strategy-based learning remains understudied. To investigate this, we trained mice on a tactile reversal learning task and implemented a trial-resolution Bayesian evidence accumulation model to measure the probability of the strategies used. We analysed multiple exploratory strategies across key task-learning phases and subsequently aft