Target engagement

First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Neuromodulatory Device-based Interventions for Psychiatric Disorders (U01 Clinical Trial Required)

National Institutes of Health

…II studies of novel agents must assess target engagement (brain exposure), pharmacological effects, safety, and tolerability to assess feasibility for Phase II/proof o

Closes Oct 15, 2027

Neuroscience

Part the Cloud: Phase 1 and Phase 2 Clinical Studies — 2027 Funding

Alzheimer’s Association

…including early human safety, target engagement and proof of mechanism. Awards provide up to USD 1 million over two to three years; selected Phase 3 or biomarker-validation proposals can also qualify. Letters of intent are due 20 October 2026 at 17:00 Eastern time (22 October for ISTAART members); invited full applications follow on 15 December (17 December for members).

Closed Oct 20

Clinical Neurology

Target engagement

Filters

When

Field

2 funding calls

First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Neuromodulatory Device-based Interventions for Psychiatric Disorders (U01 Clinical Trial Required)

Part the Cloud: Phase 1 and Phase 2 Clinical Studies — 2027 Funding