Topic: TFEB

Neurodegenerative disorders (NDs) are characterized by a progressive loss of neurons leading to broad symptoms affecting cognition and motor function. Despite extensive research efforts, treatment options remain palliative, and due to increasing incidence of NDs worldwide, novel therapies are necessary. Gene therapy represents an attractive approach for tackling the complex pathology of NDs. CRISPR-mediated gene activation (CRISPRa) encompasses a growing field of biotechnological approaches with exciting implications for gene therapy through upregulation of genetic targets of interest. However

Alzheimer’s disease (AD) presents a significant challenge to therapeutic interventions, necessitating the exploration of innovative strategies to manage its complex pathology. This study explores the relationship between autophagy and Transcription factor EB (TFEB) as a potential avenue for AD treatment. We demonstrate the therapeutic potential of TFEB in mitigating AD pathology by enhancing autophagy. Our strategy employs exosomes as vehicles for the targeted and efficient delivery of TFEB to affected cells. Exosomes, small extracellular vesicles, are recognized for their ability to cross bio