Topic: TGOT

Sociability is an extremely complex behavior that requires the involvement and coordination of different brain areas. The hypothalamic neuropeptide oxytocin (OT) plays a pivotal role in regulating various aspects of social behavior and can reach and modulate many regions of the central nervous system. However, the mechanisms through which it modulates neuronal activity are still unclear, also because this peptide can exert different effects depending on the brain area and on the neuronal type. In this work, we investigated and deepened the action of OT on a specific subpopulation of interneuro

Recent research has extended the role of the neurohormone oxytocin far beyond mating and bonding. Oxytocin now appears as a cornerstone that allows individuals to adapt their group interaction in a flexible, age and context-dependent manner. On the other hand, recent data showed that the cerebellum actually contributes to cognitive, emotional, and perceptual brain functions. Finally, both oxytocin and its receptors are present in the cerebellum, but this system remains poorly characterized.Here, we studied the effects of oxytocin-receptor (OXTR) activation on Purkinje cell activity in vitro an