Topic: thalamic nucleus reuniens

Goal-directed spatial navigation requires accurate estimates of one’s position and destination, but these estimates are still not sufficient. An animal is often required to plan a navigational route because a direct path to the goal is not necessarily available. Despite its importance, the neural circuits supporting route planning ability remain poorly understood. Previous studies have implicated the orbitofrontal cortex in representing an animal's destination, and the hippocampus in representing its own position as well as goal-directed paths. We hypothesize that interactions between these re

For an animal to obtain multiple resources in the environment, its navigation plans must be flexibly updated. This ability is thought to be supported by the hippocampus playing a pivotal role in not only mapping the animal’s own position but also replaying goal-directed paths. Whether and how spatially-tuned neurons in the hippocampus can also discriminate behavioral contexts targeting different destinations remain, however, unclear.By using a navigation task that requires frequent updates in goal locations, we found that, while a majority of place cells in the hippocampal CA1 maintained the s