Topic: therapeutic agents

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor that has a poor prognosis due to tumor recurrence and lack of effective treatment options. In order to address this challenge, we developed a novel 3D in vitro model of GBM that incorporates a co-culture of human iPSC-derived brain organoids with patient-derived GBM cells and its tumor microenvironment components. This system enables the investigation of mechanisms that lead to chemotherapy resistance and facilitates the detection of potential therapeutic agents for GBM. To establish this model, we genetically engineered patient