Topic: therapeutic hypothermia

Neonatal hypoxia-ischemia (HI), restricted oxygenation and reduced cerebral bloodflow to the brain is a significant cause of neonatal morbidity and mortality. Therapeutic Hypothermia (TH) is the only licensed treatment for HI, however, 40% of TH-treated neonates still develop neurodevelopmental disabilities. Curcumin induces powerful antioxidant activity, with evidence of significant neuroprotection in a neonatal HI mouse model. However, curcumin has limited therapeutic usage due to poor bioavailability and aqueous insolubility. This study aimed to: i) compare free synthetic vs natural curcumi

Stroke is a preeminent contributor of the global burden of diseases. Hypothermia, among other therapeutic approaches, has been proposed to promote neural survival after stroke, yet the physiological cooling remains ineffective and induces collateral side effects. The thermoregulatory mechanisms are under the control of neuronal identities that connect peripheral signals of the central nervous system, which are predominantly conveyed into the hypothalamus. Here, we aimed to identify a thermoregulatory neuronal subpopulation located at the dorsomedial hypothalamus (DMH) and investigate the DMH-p