Topic: thermal hyperalgesia

Pain is an adaptive and primordial aspect of mammal’s physiology whose role is to warn against potential harmful situations and prevent aggravation of actual physical damages. However, many patients suffer from chronic pain, which overpasses pain’s adaptive trait becoming pathological. Nociceptive signal transmission is first relayed by the spinal cord before reaching the brain through ascending pathways. The control of spinal integration descending pathway is orchestrated by the periaqueductal gray (PAG) and rostral ventromedial medulla (RVM). In the RVM, ON, OFF and neutral cells, are respec

Burns of diverse etiologies pose a significant health burden, resulting in varying levels of tissue damage and pain. Despite extensive research utilizing mouse models to elucidate burn-induced pain and recovery, discrepancies across different methodologies underscore the intricate complexity of burn pain and the necessity of standardized burn injury paradigms. To address this limitation, we developed the Burn Injury by Repeated Heat Exposure (BIRHE) model. By laying the hind paw for 10-seconds to a 52°C plate for 10 or 20 repetitions we reproducibly induce distinct pain intensities. We used th

Peripheral diabetic neuropathy (DN) affects 50% of Diabetes Mellitus (DM) patients and approximately 40-50% progress to painful diabetic neuropathy (pDN). Risk factors for pDN include high alcohol consumption, obesity, and low vitamin D levels, all associated with impaired oligodendrocyte progenitor cell (OPC) differentiation. Additionally, studies indicate that depletion of mature myelinating oligodendrocytes induces nociceptive responses in mice. These findings suggest that DM might disrupt oligodendrocyte dynamics, causing defects in central nervous system (CNS) myelin and the onset of neur