Topic: Thermal nociception

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with genetic and environmental origins. Alterations in sensory disturbance have been clinically linked to socio-emotional problems in individuals with ASD but remain understudied in the research field. Recent evidence has shown that the prefrontal cortex (PFC), a brain region plays an essential role in social cognition, is involved in pain management. Hence, this study aims to qualify nociceptive response of ASD and the implication of PFC. Valproate (VPA)-exposed offspring and Tsc2 heterozygous knockout (Tsc2+/-) mic

The renin-angiotensin system (RAS) is a key regulator of body homeostasis and is involved in modulating brain functions. Two opposing arms are thought to constitute the RAS: the pressor arm consists of Ang II, and AT1 receptors, mediating vasoconstrictor, proliferative, and proinflammatory effects, and the AT2 receptor, which opposes the effects of the AT1R. The depressor arm includes angiotensin-converting enzyme type 2 (ACE2) and Ang-(1-7), which mediate vasodilatory, antiproliferative, anti-inflammatory, and neuroprotective effects through the Mas receptor (MasR). This study aimed to elucid