Topic: theta phase

Hippocampal pyramidal (PY) spiking sequences link temporally contiguous memories by encoding sensory cues as well as temporal intervals between them, constructing trajectories across ‘memory-space’. But what is the role of inhibition – particularly parvalbumin (PV) and somatostatin expressing (SST) interneurons (INs) - in shaping such sensory and temporal representations? We pioneered longitudinal, high-frequency voltage imaging in vivo on the CA1 of PV-Cre and SST-Cre mice while they performed an odor-cued delayed non-match-to-sample task (DNMS), shown to yield odor-specific PY sequences duri

The hippocampal CA1 region continually receives a large array of intra and extra-hippocampal inputs. Local GABA-ergic interneurons in the strata radiatum and lacunosum-moleculare are thought to play a key role in structuring this incoming information. However, little is known about the in vivo electrophysiological characteristics of these superficial interneurons during behaviour. Here, we present ongoing work describing the firing properties of interneurons recorded in the stratum radiatum and lacunosum-moleculare in relation to pyramidal neuron activity and network oscillations in freely mov