Topic: tight junctions

Paclitaxel, a well-known anti-cancer drug, hinders cell division by stabilizing microtubules. Despite its effectiveness, paclitaxel causes neuropathic pain, possibly due to its impact on the immune system. The study investigated how paclitaxel affects CP macrophages, important for the blood-cerebrospinal fluid barrier. It focused on two types of Kolmer cell macrophages in a model of paclitaxel-induced neuropathic pain. Wistar rats received either paclitaxel or its vehicle (Ethanol and chromophore). Brains, including those from naïve rats, were collected at different intervals (1, 7, 14, and 21

Alzheimer's disease (AD), the leading cause of dementia, has traditionally been described as a pathology primarily affecting cognitive function with impaired neuronal and glial functioning. However, recent studies suggest that more than 75% of patients exhibit early emotional perturbations and that cerebrovascular remodeling could underlie these cognitive and emotional impairments. The aim of this study was to characterize the time of onset of anxio-depressive-like phenotype in a mouse model of AD and their potential correlation with blood-brain barrier (BBB) dysfunctions already described by

Embryonic neurodevelopment, which occurs in the sterile uterine environment, has recently been shown to be modulated by signals from the maternal gut microbiota. We hypothesised this may occur through microbial signalling to radial glial (RG) cells, which generate cortical neurons, and function as a scaffold along which new-born neurons migrate. Therefore we aimed to study the effect of maternal gut microbiota depletion during pregnancy on RG-led neurodevelopment. Female mice were treated with an antibiotic cocktail prior to and throughout pregnancy to deplete their gut microbiota. Embryonic b

The nucleus accumbens (NAc), a brain region implicated in the regulation of anxiety-related behaviors, has been found to be susceptible to blood brain barrier (BBB) permeability in psychopathologies. Additionally, the positive effects of testosterone on BBB function and anxiety related behaviours is still controversial. In this study, exploiting natural phenotypic variation in anxiety-like behaviors in outbred Wistar male rats, we aimed at investigating whether testosterone plays a role in anxiety-related BBB disfunction. We classified animals as high (HA) or low anxious (LA) according to the

Claudins are cell adhesion molecules that form a crucial component of the epithelial cells and Blood-brain barrier in vertebrates, and are structurally conserved across phyla. In their canonical role, claudins form the integral components of tight junctions where they function to regulate barrier properties. However, their interaction with other non-tight junction proteins, such as actin cytoskeleton, EpCAM suggests the possibility of non-canonical roles for claudins. Recently claudins have also been discovered in glia and neurons. Further studies have indicated a link between the loss of clau