Topic: TNFA

Stress and sleep disruption promote inflammation and metabolic adaptations, with important disease-modifying implications for psychiatric disorders. Using a novel chronic unpredictable sleep disruption (CUSD) paradigm, we characterised the impact of disrupted sleep and/or stress hormone exposure on locomotor behaviour and central markers of inflammation in the nucleus accumbens (NAc), a region implicated in regulation of mood, motivation and locomotor activity. Forty-eight Wistar rats (24 male; 24 female) were separated into groups exposed to combinations of CUSD/non-CUSD and corticosterone (2

Social stress increases susceptibility to develop substance use disorders, which can be modulated by intermittent exposure to a high-fat diet (HFD). However, both HFD and stress can elevate neuroinflammation levels under specific conditions. The objective of this study was to assess the protective role of intermittent exposure to HFD on the increase in ethanol consumption induced by social stress. The neuroinflammatory response in the hippocampus and the striatum was evaluated by quantitative real-time PCR of several gene expressions. Adult male OF1 mice were exposed to the repeated social def