Chronic latent Toxoplasma gondii infection precipitates cognitive decline in an inducible Alzheimer's disease model
Elisa Roitg, Raphaël Boursereau, Marcy Belloy, Charlotte Paut, Amel Aïda, Emilie Bassot-Parra, Benjamin Scmitt, Renzo Guiterez-Loli, Romain Ecalard, Nicolas Blanchard, Elsa Suberbielle · FENS Forum 2024
Neuroimmune dysregulations strongly contribute to the pathophysiology of Alzheimer's Disease (AD). Because pathogens shape the immune system over lifetime, their association with AD has been suggested. Increasing evidence supports a role for the prevalent, brain-persisting parasite Toxoplasma gondii (Tg) in chronic neurological diseases. Yet, the contribution of Tg chronic infection on AD clinical progression and pathogenesis remains unexplored. Considering the temporal relationship between natural Tg infection and AD occurrence, it seems legitimate to evaluate the effects of a seemingly silen
ePoster · Neuroscience