Topic: transgenic mice

A common trait of psychological disorders is an impairment in executing appropriate action under conflicting motivations. Indeed, balancing reward and risk is a fundamental brain process essential for survival. The brain assigns positive or negative value to external stimuli, facilitating approach or avoidance behaviors, respectively. Thus, dissecting the brain circuitry that controls these processes is essential towards a better understanding of brain function and the pathological processes in mental health. The laterodorsal tegmental area (LDTg) is a heterogeneous brain region which modulate

Tauopathies are leading cause of loss of autonomy in the elderly, implying a progressive cognitive decline. There is not an effective treatment early diagnosis of tauopathies. We propose an in-vitro and theragnostic approach by using a novel phosphorylated Tau(p-Tau) monoclonal antibody(mAb) responsible for tau self-aggregation and regulation.A diagnostic Sandwich ELISA kit was developed and tested in 89 cerebrospinal fluid (CSF) samples of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) patients for detection of p-Tau.The proof of concept study reported specific signals above the