Topic: transmembrane domain

The synergistic effects on neuronal plasticity of acute glucocorticoids levels increase and the BDNF-TRKB signaling indicate a deep interconnection between the two pathways. Moreover, chronic stress with elevated glucocorticoids levels and downregulation of TRKB signaling associated with reduced BDNF are both involved in the pathophysiology of different psychiatric disorders.In this study we investigated in vitro the molecular mechanisms underlying the interplay of glucocorticoids and TRKB signaling. We found that the glucocorticoid receptor physically interacts with TRKB, modulating its dimer

Aims: Following the seminal description of a de novo GABRA4 variant associated with early onset epilepsy and developmental delay, additional variants from patients and healthy controls are investigated.Methods: We collected molecular and phenotype data of individuals carrying de novo variants in GABRA4. A total of four patients and their parents were investigated either by exome or genome sequencing, followed by targeted Sanger sequencing in some cases. The variants are investigated utilizing molecular dynamics (MD) simulation studies, and functional studies using two electrode voltage clamp s