Topic: traumatic memories

Post-traumatic stress disorder affects millions worldwide, with low therapeutic success. Research confirms the involvement of memory processes in pathological and persistent traumatic memories that are difficult to overwrite. Previously, in an animal model, we demonstrated that the extinction can be expedited by closed-loop (CL) stimulation of the medial forebrain bundle (MFB) triggered by sharp-wave ripple (SWR) patterns. Similarly, stimulation of the infralimbic cortex (IL) timed to SWR also maintained a low level of fear response over the long term.We aimed to investigate if the manipulatio

Early-life adversity (ELA) is a leading risk factor for developing mental disorders such as depression or anxiety in adulthood. Some of its anatomical and molecular correlates were described under multiple stress paradigms, acute and chronic alike, in various species. However it is unclear how the cellular substrate of traumatic memories associated with ELA evolves through life and can participate in its behavioral outcome. To allow lifelong tracking of neuronal populations recruited during early-life stress we used FosTRAP2 mice in a juvenile (P21) social defeat model (jSD), in which neuronal