Topic: Traumatic spinal cord injury

At present, no effective therapies are available for traumatic spinal cord injury (SCI). Following the initial trauma, persistent inflammation exacerbates neuronal and functional losses. Our recent findings highlight the potential of acute treatment with MSC-derived extracellular vesicles (MSC-EVs) in mitigating inflammation and its consequential damages after SCI. However, with numerous protocols available for EV preparation from MSC-derived secretomes, we sought to identify the most efficacious method for generating EV preparations capable of reducing the pro-inflammatory polarization of mic

Traumatic spinal cord injury (SCI) leads to the immediate activation of the hypothalamus-pituitary-adrenal (HPA) axis. However, its proper function is impaired due to primary and secondary injury to the neural pathways of the sympathetic nervous system innervating the adrenal gland. Disruption of sympathetic innervation can strongly influence the expression of Angiotensin II receptors that are found at all levels of HPA axis. In this study, circulating Angiotensin II levels and the expression of Angiotensin II receptors within HPA axis after compression-induced SCI (40g weight for 15 min) at t