Topic: treadmill running

In our previous studies, we developed a marker-based 3D motion capture system to evaluate step kinematics during behaviors such as climbing and novel environment exploration under various pharmacological treatments. In the present study, we aimed to test whether the step kinematics of mice is affected during treadmill running at different speeds and under various treatments. We used adult male C57BL/6 mice in a within-subject, randomized design. We recorded voluntary running behavior on a treadmill in mice treated with vehicle (1:1:18 ethanol, Kolliphor, saline), CP55,940 (0.3 mg/kg) or harmal

Regular aerobic endurance exercise has been considered to have neuroprotective effects, with recent evidence suggesting its potential role in modulating inflammatory mediators and microglia states and functions in the central nervous system. Most of the published data to date have been generated using male mice, hence the effects of both exercise and experimentally-induced neuroinflammation are less well-investigated, and hence are less well-understood in female mice.Here, we investigated the impact of 7 consecutive days of low-to-moderate-intensity treadmill running on microglial activation i