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Topic: TRIO

ePoster
2 ePosters

In Neuroscience

Heterozygosity for neurodevelopmental disorder-associated TRIO variants leads to distinct deficits in neuronal development and function

Yevheniia Ishchenko, Amanda T. Jeng, Shufang Feng, Timothy Nottoli, Melissa G. Carrizales, Matthew J. Vitarelli, Ellen Corcoran, Cindy Manriquez-Rodriguez, Khanh Nguyen, Charles A. Greer, Samuel A. Myers, Anthony J. Koleske · FENS Forum 2024

TRIO is a high-risk gene for schizophrenia (SCZ) and autism spectrum disorder (ASD) also variants found in patients with bipolar disorder (BPD). TRIO regulates small-GTPases to control neuronal migration, synapse development and function. However, it remains unclear whether and how discrete TRIO variants differentially impact these neurodevelopmental events. Here, we use murine models to investigate heterozygous variants that impact TRIO catalytic activity and are linked to NDDs: (TRIO) +/K1431M (ASD), +/K1918X (SCZ), and +/M2145T (bipolar disorder, BPD). Heterozygosity for Trio variants impac

ePoster · Neuroscience

Identification of blood and neuronal biomarkers for disease onset and medication response in first-episode psychosis patients

Olga Rivero, Kito McKenzie, Àngela Nativitat, Hristina Uzunova, Alba Postiguillo, María José Escartí, Javier David Lluesma, Maria Dolores Moltó · FENS Forum 2024

Schizophrenia (SZ) is a heterogeneous neuropsychiatric disorder whose complexity has hampered the identification of biomarkers that are actually useful in the clinical practice. Our study is based on the hypothesis that first-episode psychosis (FEP) patients present altered gene expression in blood that correlates with changes in neurons. We have analyzed the expression of genes (associated with SZ in genomic studies) through real-time PCR in peripheral blood from 63 FEP patients and 83 controls. We observed that TOX gene was significantly altered in male patients when compared to male control

ePoster · Neuroscience