Topic: TRPM2

Recent studies have highlighted the pivotal role of TRPM2 channel activation in neurological disorders. Nevertheless, its association with epileptic seizures and subsequent neuronal damage remains unclear. This study aims to investigate the impact of inhibiting TRPM2 on 4-AP-induced seizures in mouse brain slices and the resultant neuronal damage in the HT-22 cell line. Electrophysiologically using LFP records the effect of TRPM2 inhibition through the TRPM2 antagonist N-ACA was demonstrated in the entorhinal cortex region after the 4-AP-induced seizure model. Furthermore, to shed light on the

The major function of primary order neurons in the ARC of the hypothalamus is control of energy homeostasis. Among these neurons, POMC neurons play a significant role in controlling anorexigenic feeding behavior and upregulating energy expenditure. Additionally, TRPM2 is a well-established temperature sensor, but no evidence of regulation of BAT thermogenesis via POMCTRPM2 neurons in the ARC has been reported to date. We here investigated the role of ARC POMCTRPM2 in BAT thermogenesis. Through single-cell RT-PCR and IHC analyses, we confirmed that some POMC neurons express TRPM2. The specific