Topic: Tumor-associated macrophages

Malignant peripheral trigeminal sheath tumor (MPNST) spreads to the brain parenchyma via the perivascular space (PVS). Nestin-expressing neoplastic cells lead tumor progression. Tumor-associated macrophages and microglia (TAMs) are a critical immune cells population for promoting this progression. In this work, we study the distribution of Nestin+ cells and TAMs in the infiltrative perivascular spaces of endogenous rat MPNSTs.MPNSTs are induced in Sprague Dawley rats by prenatal exposure of N-Ethyl N-nitrosourea (ENU). Tumor screening is performed by T1-w Magnetic Resonance Imaging and by immu

Spinal Cord Injury (SCI) is a dramatic and irreversible event that leads to the loss of motor and/or sensory functions. After complete SCI, such as grade ASIA-A lesions, the neural tissue fails to repair causing permanent neurological deficits. Nowadays, complete SCI represents an unmet medical need, with no treatments capable to reduce cell death, heal the neural parenchyma, and promote axonal regrowth. In this work, we have identified a set of tumor-associated macrophages with neurogenic properties opening the prospective for a new effective cell therapy for neural degeneration diseases. We