Topic: TurboID

Throughout development, the brain dynamically regulates the composition of its extracellular fluid compartments. Proteins secreted into these compartments, defined collectively as the brain secretome, have been shown to influence key neurodevelopmental processes from cell migration to synaptogenesis. Nonetheless, only a fraction of the brain secretome has been comprehensively characterized, leaving the developmental contribution of many disorder-associated secreted proteins unexplored. A growing body of literature highlights the dysregulation of extracellular fluids in the brain as a common fe

The serotonin 5-HT6 receptor (5-HT6R) is a G protein-coupled receptor only expressed in the central nervous system. It is a promising target for treating cognitive deficits observed in neurodevelopmental diseases, such as autism spectrum disorders (ASD). Our team has demonstrated a crucial role for the 5-HT6R in neurodevelopment. It participates in neuronal migration, the initiation of neurite growth and dendritic arborization, through interactions with different protein partners. We also confirmed that this receptor is mainly expressed in the primary cilium of neurons and astrocytes, except f