Turning neurons RIV, SMB, and SAAD gates mechanosensory response in C. elegans upstream of AVA
An important goal of the nervous system is to integrate sensory cues with an animal’s current behavior state to generate a suitable motor response. However, the underlying neuronal mechanism behind how neural circuits integrate sensory and behavior signals remains unknown. To answer this question, we performed a systematic high-throughput optogenetic interrogation of the neural circuits underlying mechanosensorimotor processing in the nematode C. elegans. When C. elegans detects gentle touch from the environment, it usually responds by moving backward, also known as reversals. The likelihood o
Sat, Mar 11, 2023