Topic: two-photon recordings

The retina transforms patterns of light into visual feature representations supporting behaviour. In the mouse, these representations are distributed across more than 30 types of retinal ganglion cells (RGCs), whose spatial and temporal tuning properties have been studied extensively. However, a systematic approach for linking the often nonlinear retinal transformations of natural visual inputs to specific ethological purposes is lacking. Here, we trained a convolutional neural network model (CNN) on large-scale functional two-photon recordings of RGC responses to natural mouse movies, and the

The increasing prevalence of psychiatric disorders, such as depression, highlights the need to elucidate their underlying neurobiological mechanisms. The lateral habenula (LHb) and its neuronal activity contribute to the pathophysiology of depression when dysfunctional. Among the existing rodent models of depression, chronic corticosterone administration for 3-4 weeks recapitulates relevant behavioural aspects of the disease such as anhedonia and increased passive coping. However, the temporal emergence of these features and the cellular underpinnings remain unclear. Thus, we assessed the emer