Studying the effect of chronic peripheral inflammation, via transurethral instillation of LPS, on neuroplasticity
Alaa El Makkawi, Rami Arnaout, Batoul Darwish, Sana Hachem, Nayef Saadeh, Wassim Abou-Kheir · FENS Forum 2024
Previous reports showed that many cognitive deficits arise in patients exhibiting symptoms of urinary tract infections (UTI) including neuropsychiatric disorders. In our laboratory, we have shown that E-coli induced UTI in adult rats caused a significant decrease in neurogenesis and impaired cognitive and memory skills. No studies have explored the mechanism of action and the effect of chronic inflammation mimicking UTI on neurogenesis and brain plasticity. Here, we aim to investigate the effect of chronic peripheral inflammation via lipopolysaccharide (LPS) instillation in the urothelium on c
ePoster · Neuroscience