Topic: V2a neurons

Axial proprioceptive sensory feedback plays a crucial role in modulating locomotion, enabling vertebrates to dynamically adjust motor output in response to body movements and environmental forces. In this study, we present a spiking neuromechanical model of the zebrafish, focusing on how proprioceptive signals from Piezo2-expressing neurons modulate the activity of the spinal cord's central pattern generator (CPG) network, thus regulating the locomotor output. A spiking neural network comprising the main classes of interneurons in the zebrafish locomotor circuits, namely V2a, V0d and motoneur

The brainstem reticular formation (RF) is key for controlling movements, both at the spinal (e.g., trunk, limbs) and at supra-spinal (e.g., orofacial, ocular) levels. Yet, in this heterogenous structure, the specific contributions of discrete cellular populations to identified unitary actions remain poorly understood. The V2a identity (Chx10-expressing) circumscribes a subgroup of glutamatergic neurons along the rostrocaudal axis of the pontomedullary RF. In the mouse, those located in the gigantocellular reticular nucleus (GRN) were shown to control limb and head-related motor components of o