Topic: vasoconstriction

Neurovascular coupling (NVC), the tight coupling between neural activity and cerebral blood flow (CBF), is essential for brain function and integrity. Decreased CBF and altered NVC are among the earliest biomarkers of Alzheimer’s disease (AD) and may exacerbate its progression. Among the various cellular players of NVC, cyclooxygenase-2 (COX2) pyramidal cells, play a key role via the release of prostaglandin E2 (PGE2), which can bidirectionally control the NVC. We investigated the role of pyramidal cells in neurovascular uncoupling of AD using cortical slices from triple transgenic mice expres

Spreading Depolarizations (SDs) are electrographic events that arise post-stroke and correlate with worsening outcome. The haemodynamic response to SD is vasodilation in well perfused tissue. However, SDs induce hypoperfusion in ischemic tissue, further decreasing the viability of ‘at risk’ tissue.Traditional metal-based electrodes are limited in their ability to faithfully record DC-coupled potential shifts including SD. In contrast, Graphene micro-transistor arrays (gSGFETs) precisely record SDs without signal attenuation, distortion or voltage drift; and their transparency allows simultaneo