Topic: ventral subiculum

The hippocampal formation is a crucial region in the encoding and retrieval of memory, thought to be mediated through ensemble formation and recruitment or intrinsic attractor dynamics. Additionally, it has been shown that overall hippocampal population activity reflects environmental novelty. However, a common neural basis supporting these two processes remains unknown. Furthermore, many memories contain overlapping features, and it remains to be established how specific memories are retrieved without interference in the hippocampus. We propose that both engram and attractor models hinge on l

A growing body of evidence indicates a functional dichotomy between the dorsal (dHC) and ventral poles of the hippocampus (vHC). Specifically, the dorsal region is implicated in encoding spatial information and episodic memories, whereas the ventral region is recognized for its role in processing the emotional aspects associated with those memories. The medial septum/diagonal band of Broca complex (MSDB) plays pivotal role in both cognitive and emotional functions, implying anatomically distinct pathways of MSDB efferents conducting information to dHC and vHC, respectively. To test this, we tr

The circuitry underlying the initiation, maintenance, and coordination of wakefulness, rapid eye movement sleep, and non-rapid eye movement sleep is not thoroughly understood. Sleep is thought to arise due to decreased activity in the ascending reticular arousal system, which originates in the brainstem and awakens the thalamus and cortex during wakefulness. Despite the conventional association of sleep-wake states with hippocampal rhythms, the mutual influence of the hippocampal formation in regulating vigilance states has been largely neglected. Here, we focus on the subiculum, the main outp

The dorsal midline thalamus (dMT) is a group of non-sensory thalamic nuclei that has been implicated in arousal and in the homeostatic maintenance of sleep choreography. Neocortical slow oscillations and hippocampal sharp wave ripples (SPW-R) are the hallmarks of non-rapid eye-movement (NREM) sleep and reflect synchronous activation of neocortical and hippocampal neuronal ensembles, respectively. The dMT is reciprocally connected both with the neocortex and with the hippocampal system, however, little is known about their interaction during sleep. We performed large-scale unit recordings from