Topic: ventricular zone

Understanding the neurodevelopment of cerebellar nuclei (CN), the primary output of the cerebellum, is crucial. Traditionally, the rhombic lip (RL) and ventricular zone (VZ) have been known as the origins of glutamatergic excitatory and GABAergic inhibitory CN neurons, which emerge after embryonic day 9 (E9). However, our study uncovers a novel subset of cells in the nuclear transitory zone (NTZ), a transient area for future CN that appears even before E9. Our study’s objective is to map the fate of these early-appearing cells in the developing cerebellum. Utilizing SncaGFP transgenic mice, th

After neurulation, neuroprogenitor cells differentiate into postmitotic neurons that migrate away from the ventricular zone and form a laminated structure in the spinal cord. Semaphorins are crucial for neuronal differentiation, particularly in axon pathfinding. Although semaphorin receptors are expressed in the ventricular zone of the developing spinal cord, their role in the neuronal cell cycle is not yet clear. Our study suggests that Sema 3 and their neuropilin receptors may be involved in a process that we disrupted using in-ovo electroporation. We overexpressed dominant-negative forms of