Topic: VIP interneurons

Although distinct cortical regions specialize in different functions, they also benefit from receiving global reinforcement feedback to tune local processing. When and how those reinforcement signals shape cortical computations remains however largely unknown. Here, we present experimental evidence showing that acetylcholine inputs throughout the cortex form the backbone for a global signal, that presents the main characteristic of an unsigned reinforcement prediction error computation : modulation of the reinforcement response by expectation and coding of predictive cues. We show that this gl

The subiculum, a hippocampal subfield that functions as the final gate for most hippocampal outputs, is implicated in various psychiatric disorders. Accumulating evidence suggests that dysfunction in multiple GABAergic interneuron types is a key factor in the pathologic presentation of hippocampal hyperactivity associated with these disorders. We posit that dysfunction in the inhibitory control of interneurons in the subiculum may be a key network mechanism for the emergence of hippocampal hyperactivity. In several brain regions, a special class of interneurons known as vasoactive intestinal p