Topic: viral infections

Recently found association linking viral infections to neurodegenerative diseases has raised concerns about unknown mechanisms in the communication between the respiratory and central nervous systems . We hypothesized that extracellular vesicles (EVs) can transfer viral signals to microglia, triggering the upregulation of pro-inflammatory cytokines by activating inflammasome-related pathways. In this study, we investigate the role of EVs released from virus mimetic poly I:C-infected human airway epithelial cells in modulating microglial immune responses. EVs were isolated from poly I:C-primed

A growing body of evidence suggests a potential link between neuroinflammation, directly or indirectly triggered by viral infections, and the initiation or progression of neurodegenerative diseases such as Parkinson's disease (PD). Viral infections can potentially induce pathological alterations in amyloidogenic proteins such as a-synuclein (αSyn) implicated in pathogenesis of this disease. However, the exact molecular mechanisms of virus-induced neuroinflammation remain unclear.To get insights into mechanisms of viral RNA-induced neurotoxicity, we treated rat neuronal-glial co-cultures (CGC)