Topic: visceral hypersensitivity

Modification of the olfactory system can dramatically influence emotion and it is well accepted that mice with olfactory impairments develop pseudo-depressive symptoms (Yuan. M. et al, 2020) and microbiota dysregulation (Shuai-Ming Zhu et al, 2024). On this backdrop, our research is currently focusing on the therapeutic potential of exploiting the olfactory system in mood-related disorders. Different odors can exert anxiolytic and/or antidepressant-like effects in several depression models. To better understand the functional relationships between odors, emotion, microbiota and gut physiology

Emerging studies have demonstrated that neural-immune interactions play a critical role in gastrointestinal diseases. Sympathetic neural system (SNS) activity, susceptible to stress modulation, has been elucidated for its direct impact on immune cells through adrenergic receptors, or alternatively, its indirect influence via the modulation of proinflammatory chemical release. However, sympathetic neural-immune interactions in the gastrointestinal tract and their contribution to visceral pain are still unclear. Here, we established an early life stress model with gastrointestinal disorder. In t