Neural correlates of social choices during decision-making in freely moving mice
Dimokratis Karamanlis, Andrea Valderrama Alvarez, Anas Masood, Sami El-Boustani · FENS Forum 2024
Humans and social animals interpret the body language of others to infer intentions and adjust their actions instantaneously. To explore neural representations of conspecific kinematics during goal-directed behavior, we trained pairs of freely moving mice to jointly perform a two-alternative forced-choice task. The mice had to discriminate the location of a visual grating to earn water rewards. Using high-speed videography, we showed that mice engage in stereotypical trajectories from the trial initiation site to the chosen reward lick port across hundreds of trials. By decomposing movement in