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Topic: visual grating

ePoster
2 ePosters

In Neuroscience

ePoster · Neuroscience

Neural correlates of social choices during decision-making in freely moving mice

Dimokratis Karamanlis, Andrea Valderrama Alvarez, Anas Masood, Sami El-Boustani · FENS Forum 2024

Humans and social animals interpret the body language of others to infer intentions and adjust their actions instantaneously. To explore neural representations of conspecific kinematics during goal-directed behavior, we trained pairs of freely moving mice to jointly perform a two-alternative forced-choice task. The mice had to discriminate the location of a visual grating to earn water rewards. Using high-speed videography, we showed that mice engage in stereotypical trajectories from the trial initiation site to the chosen reward lick port across hundreds of trials. By decomposing movement in

Gamma oscillations are believed to arise from the interaction between excitation and inhibition (E-I) in the neural circuitry. However, the dependency of gamma power on E-I interaction is not well characterized. Increasing the drift-rate of the visual grating, which changes E-I balance, increases the peak frequency of gamma while power initially increases and later attenuates. Importantly, this power versus drift-rate tuning curve is altered for subjects with autism or premenstrual dysphoric disorder. A recent MEG study in humans (Orekhova et al., 2020) examined the combined effect of contrast