Topic: visual oddball task

How the brain processes a stimulus depends not only on its physical properties but also on contextual factors, such as whether it is predictable, expected, or surprising. Though well characterized using non-invasive means, the microcircuit mechanisms responsible for comparing sensory input and expectations remain poorly understood. We recorded single units and local field potential (LFP) activity from primary visual cortex in awake mice engaged in a visual oddball task. Relative to stimulus onset, we distinguish early (50-200ms) and late (200-400ms) neural response windows, a choice compatible

Schizophrenia is a neuropsychiatric disorder that is strongly associated with impairments in both basic sensory processing and higher cognitive functions. One of the most robust findings is that Schizophrenia patients have deficient sensory processing and impairment can be captured by the reduced “mismatch negativity” (MMN), which is an event-related potential that occurs when a sequence of repetitive stimuli is interrupted by occasional oddball stimuli. Although MMN is the biomarker of Schizophrenia and robustly translational across species, the underlying mechanisms of MMN are not clear. To