Topic: vocalization

Stimulation of the Periaqueductal Gray matter (PAG) and nucleus retroambiguus (nRA) evokes vocalization. nRA modulates the activity of laryngeal motoneurons located in the nucleus ambiguus (nA). We have demonstrated the involvement of rostral and ventral pontine structures in altering laryngeal caliber. A heightened expression of the FOXP2 protein was described in both PAG and pontine regions implicated in cardiorespiratory control.To investigate the interactions between the dlPAG and neurons of the nA assessing the double staining patterns of c-Fos/FOXP2 protein immunoreactivity (c-Fos-ir/FOX

The transcription factor FOXP2 is a regulator of vocalization-, speech-, and language-related phenotypes in human and non-human species. The FOXP2 protein contains multiple domains including a DNA-binding forkhead domain, a zinc finger domain, a leucine zipper, and N-terminal polyglutamine (polyQ) repeats. We have recently found that the FOXP2 N-terminal polyQ region drives the liquid-liquid phase separation (LLPS) of the protein. FOXP2 LLPS is regulated by the evolutionary length variation of the polyQ repeats and has a role in modulating the transcriptional activity of the protein. The poten

Human speech allows to convey information via different execution forms. Thus, on the behavioral level, speech content is independent from production and execution forms. However, it remains unclear whether such a content dimension can be found on the neural level and whether it is possible to dissociate it from the motor dimension. To address this, we recorded magnetoencephalography (MEG) in human subjects that performed two rule-based vocalization tasks. In the first experiment, content (one of two vowels) and production (overt or covert) were instructed separately and in random order. Apply